Endocrine Abstracts

Somatostatin (SST), Cortistatin (CORT), ghrelin, and their corresponding receptors (ssts and GHS-R) are closely interrelated systems involved in the regulation of essential hormones for metabolic homeostasis, like insulin, whose release is inhibited by SST/CORT and stimulated by ghrelin. To investigate the underlying mechanisms of this insulin regulation, we analyzed the expression of such systems at pancreatic level in wild type (WT) and CORT knock-out mice (CORT-KO) under bo...